Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 897-902 |
| Seitenumfang | 6 |
| Fachzeitschrift | Nature Methods |
| Jahrgang | 14 |
| Ausgabenummer | 9 |
| Frühes Online-Datum | 14 Aug. 2017 |
| Publikationsstatus | Veröffentlicht - 1 Sept. 2017 |
Abstract
We present a broadly applicable, user-friendly protocol that incorporates sparse and hybrid experimental data to calculate quasi-atomic-resolution structures of molecular machines. The protocol uses the HADDOCK framework, accounts for extensive structural rearrangements both at the domain and atomic levels and accepts input from all structural and biochemical experiments whose data can be translated into interatomic distances and/or molecular shapes.
ASJC Scopus Sachgebiete
- Biochemie, Genetik und Molekularbiologie (insg.)
- Biotechnologie
- Biochemie, Genetik und Molekularbiologie (insg.)
- Biochemie
- Biochemie, Genetik und Molekularbiologie (insg.)
- Molekularbiologie
- Biochemie, Genetik und Molekularbiologie (insg.)
- Zellbiologie
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in: Nature Methods, Jahrgang 14, Nr. 9, 01.09.2017, S. 897-902.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - M3
T2 - an integrative framework for structure determination of molecular machines
AU - Karaca, Ezgi
AU - Rodrigues, João P.G.L.M.
AU - Graziadei, Andrea
AU - Bonvin, Alexandre M.J.J.
AU - Carlomagno, Teresa
N1 - Funding Information: This work was supported by the EMBL, the EU FP7 ITN project RNPnet (contract number 289007) and the DFG grant CA294/3-2. E.K. acknowledges support from the Alexander von Humboldt Foundation through a Humboldt Research Fellowship for Postdoctoral Researchers. We thank J. Kirkpatrick for critical reading of the manuscript and B. Simon for discussion and support with CNS. A.M.J.J.B. acknowledges funding from the European H2020 e-Infrastructure grants West-Life (grant no. 675858) and BioExcel (grant no. 675728). Publisher Copyright: © 2017 Nature America, Inc., part of Springer Nature. All Rights Reserved. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2017/9/1
Y1 - 2017/9/1
N2 - We present a broadly applicable, user-friendly protocol that incorporates sparse and hybrid experimental data to calculate quasi-atomic-resolution structures of molecular machines. The protocol uses the HADDOCK framework, accounts for extensive structural rearrangements both at the domain and atomic levels and accepts input from all structural and biochemical experiments whose data can be translated into interatomic distances and/or molecular shapes.
AB - We present a broadly applicable, user-friendly protocol that incorporates sparse and hybrid experimental data to calculate quasi-atomic-resolution structures of molecular machines. The protocol uses the HADDOCK framework, accounts for extensive structural rearrangements both at the domain and atomic levels and accepts input from all structural and biochemical experiments whose data can be translated into interatomic distances and/or molecular shapes.
UR - http://www.scopus.com/inward/record.url?scp=85028715684&partnerID=8YFLogxK
U2 - 10.1038/nmeth.4392
DO - 10.1038/nmeth.4392
M3 - Article
C2 - 28805795
AN - SCOPUS:85028715684
VL - 14
SP - 897
EP - 902
JO - Nature Methods
JF - Nature Methods
SN - 1548-7091
IS - 9
ER -