Lipid-based nanodelivery systems of curcumin: Recent advances, approaches, and applications

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Autoren

  • Asli Can Karaca
  • Atefe Rezaei
  • Muhammad Qamar
  • Elham Assadpour
  • Tuba Esatbeyoglu
  • Seid Mahdi Jafari

Externe Organisationen

  • Technische Universität Istanbul
  • Isfahan University of Medical Sciences
  • Bahauddin Zakariya University
  • Gorgan University of Agricultural Sciences and Natural Resources (GUASNR)
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Details

OriginalspracheEnglisch
Aufsatznummer141193
FachzeitschriftFood Chemistry
Jahrgang463
Ausgabenummer2
Frühes Online-Datum11 Sept. 2024
PublikationsstatusElektronisch veröffentlicht (E-Pub) - 11 Sept. 2024

Abstract

Despite its many beneficial effects, pharmaceutical applications of curcumin (CUR) are limited due to its chemical instability, low solubility/absorption and weak bioavailability. Recent advances in nanotechnology have enabled the development of CUR-loaded nanodelivery systems to tackle those issues. Within many different nanocarriers developed for CUR up to date, lipid-based nanocarriers (LBNs) are among the most extensively studied systems. LBNs such as nanoemulsions, solid lipid carriers, nanostructured phospholipid/surfactant carriers are shown to be potential delivery systems capable of improving the solubility, bioavailability, and chemical stability of CUR. The particle characteristics, stability, bioavailability, and release properties of CUR-loaded LBNs can be tailored via optimizing the formulation and processing parameters. This paper reviews the most recent studies on the development of various CUR-loaded LBNs. Approaches to the improvement of CUR bioavailability and release characteristics of LBNs are discussed. Furthermore, challenges in the development of CUR-loaded LBNs and their potential applications are presented.

ASJC Scopus Sachgebiete

Zitieren

Lipid-based nanodelivery systems of curcumin: Recent advances, approaches, and applications. / Can Karaca, Asli; Rezaei, Atefe; Qamar, Muhammad et al.
in: Food Chemistry, Jahrgang 463, Nr. 2, 141193, 15.01.2025.

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Can Karaca, A., Rezaei, A., Qamar, M., Assadpour, E., Esatbeyoglu, T., & Jafari, S. M. (2025). Lipid-based nanodelivery systems of curcumin: Recent advances, approaches, and applications. Food Chemistry, 463(2), Artikel 141193. Vorabveröffentlichung online. https://doi.org/10.1016/j.foodchem.2024.141193
Can Karaca A, Rezaei A, Qamar M, Assadpour E, Esatbeyoglu T, Jafari SM. Lipid-based nanodelivery systems of curcumin: Recent advances, approaches, and applications. Food Chemistry. 2025 Jan 15;463(2):141193. Epub 2024 Sep 11. doi: 10.1016/j.foodchem.2024.141193
Can Karaca, Asli ; Rezaei, Atefe ; Qamar, Muhammad et al. / Lipid-based nanodelivery systems of curcumin: Recent advances, approaches, and applications. in: Food Chemistry. 2025 ; Jahrgang 463, Nr. 2.
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abstract = "Despite its many beneficial effects, pharmaceutical applications of curcumin (CUR) are limited due to its chemical instability, low solubility/absorption and weak bioavailability. Recent advances in nanotechnology have enabled the development of CUR-loaded nanodelivery systems to tackle those issues. Within many different nanocarriers developed for CUR up to date, lipid-based nanocarriers (LBNs) are among the most extensively studied systems. LBNs such as nanoemulsions, solid lipid carriers, nanostructured phospholipid/surfactant carriers are shown to be potential delivery systems capable of improving the solubility, bioavailability, and chemical stability of CUR. The particle characteristics, stability, bioavailability, and release properties of CUR-loaded LBNs can be tailored via optimizing the formulation and processing parameters. This paper reviews the most recent studies on the development of various CUR-loaded LBNs. Approaches to the improvement of CUR bioavailability and release characteristics of LBNs are discussed. Furthermore, challenges in the development of CUR-loaded LBNs and their potential applications are presented.",
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AU - Can Karaca, Asli

AU - Rezaei, Atefe

AU - Qamar, Muhammad

AU - Assadpour, Elham

AU - Esatbeyoglu, Tuba

AU - Jafari, Seid Mahdi

N1 - Copyright © 2024 Elsevier Ltd. All rights reserved. Publisher Copyright: © 2024 Elsevier Ltd

PY - 2024/9/11

Y1 - 2024/9/11

N2 - Despite its many beneficial effects, pharmaceutical applications of curcumin (CUR) are limited due to its chemical instability, low solubility/absorption and weak bioavailability. Recent advances in nanotechnology have enabled the development of CUR-loaded nanodelivery systems to tackle those issues. Within many different nanocarriers developed for CUR up to date, lipid-based nanocarriers (LBNs) are among the most extensively studied systems. LBNs such as nanoemulsions, solid lipid carriers, nanostructured phospholipid/surfactant carriers are shown to be potential delivery systems capable of improving the solubility, bioavailability, and chemical stability of CUR. The particle characteristics, stability, bioavailability, and release properties of CUR-loaded LBNs can be tailored via optimizing the formulation and processing parameters. This paper reviews the most recent studies on the development of various CUR-loaded LBNs. Approaches to the improvement of CUR bioavailability and release characteristics of LBNs are discussed. Furthermore, challenges in the development of CUR-loaded LBNs and their potential applications are presented.

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KW - Encapsulation

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