Isolation and total synthesis of icumazoles and noricumazoles-antifungal antibiotics and cation-channel blockers from Sorangium cellulosum

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Autorschaft

  • Jenny Barbier
  • Rolf Jansen
  • Herbert Irschik
  • Stefan Benson
  • Klaus Gerth
  • Bettina Böhlendorf
  • Gerhard Höfle
  • Hans Reichenbach
  • Jens Wegner
  • Carsten Zeilinger
  • Andreas Kirschning
  • Rolf Müller

Externe Organisationen

  • Helmholtz-Zentrum für Infektionsforschung GmbH (HZI)
  • DSM Food Specialties
Forschungs-netzwerk anzeigen

Details

Titel in ÜbersetzungIsolierung und Totalsynthese der Icumazole und Noricumazole – antimykotische Antibiotika und Kationenkanalblocker aus Sorangium cellulosum
OriginalspracheEnglisch
Seiten (von - bis)1256-1260
Seitenumfang5
FachzeitschriftAngewandte Chemie
Jahrgang51
Ausgabenummer5
PublikationsstatusVeröffentlicht - 23 Dez. 2011

Abstract

Joint efforts: The antifungal icumazole A, the potassium-ion-channel inhibitor noricumazole A, and their glycosylated derivatives are new, structurally related secondary metabolites isolated from Sorangium cellulosum. Their structures have been fully assigned by a joint strategy that relied on spectroscopy, derivatization, fragmentation, and finally the first total synthesis of noricumazole A.

ASJC Scopus Sachgebiete

Zitieren

Isolation and total synthesis of icumazoles and noricumazoles-antifungal antibiotics and cation-channel blockers from Sorangium cellulosum. / Barbier, Jenny; Jansen, Rolf; Irschik, Herbert et al.
in: Angewandte Chemie , Jahrgang 51, Nr. 5, 23.12.2011, S. 1256-1260.

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Barbier J, Jansen R, Irschik H, Benson S, Gerth K, Böhlendorf B et al. Isolation and total synthesis of icumazoles and noricumazoles-antifungal antibiotics and cation-channel blockers from Sorangium cellulosum. Angewandte Chemie . 2011 Dez 23;51(5):1256-1260. doi: 10.1002/anie.201106435, 10.1002/ange.201106435, 10.1002/anie.201201953, 10.1002/ange.201201953
Barbier, Jenny ; Jansen, Rolf ; Irschik, Herbert et al. / Isolation and total synthesis of icumazoles and noricumazoles-antifungal antibiotics and cation-channel blockers from Sorangium cellulosum. in: Angewandte Chemie . 2011 ; Jahrgang 51, Nr. 5. S. 1256-1260.
Download
@article{181804b65d1f496997c8d89fb40ae0ed,
title = "Isolation and total synthesis of icumazoles and noricumazoles-antifungal antibiotics and cation-channel blockers from Sorangium cellulosum",
abstract = "Joint efforts: The antifungal icumazole A, the potassium-ion-channel inhibitor noricumazole A, and their glycosylated derivatives are new, structurally related secondary metabolites isolated from Sorangium cellulosum. Their structures have been fully assigned by a joint strategy that relied on spectroscopy, derivatization, fragmentation, and finally the first total synthesis of noricumazole A.",
keywords = "antibiotics, ion-channel inhibitors, myxobacteria, natural products, structure elucidation, total synthesis",
author = "Jenny Barbier and Rolf Jansen and Herbert Irschik and Stefan Benson and Klaus Gerth and Bettina B{\"o}hlendorf and Gerhard H{\"o}fle and Hans Reichenbach and Jens Wegner and Carsten Zeilinger and Andreas Kirschning and Rolf M{\"u}ller",
year = "2011",
month = dec,
day = "23",
doi = "10.1002/anie.201106435",
language = "English",
volume = "51",
pages = "1256--1260",
journal = "Angewandte Chemie ",
issn = "1433-7851",
publisher = "John Wiley and Sons Ltd",
number = "5",

}

Download

TY - JOUR

T1 - Isolation and total synthesis of icumazoles and noricumazoles-antifungal antibiotics and cation-channel blockers from Sorangium cellulosum

AU - Barbier, Jenny

AU - Jansen, Rolf

AU - Irschik, Herbert

AU - Benson, Stefan

AU - Gerth, Klaus

AU - Böhlendorf, Bettina

AU - Höfle, Gerhard

AU - Reichenbach, Hans

AU - Wegner, Jens

AU - Zeilinger, Carsten

AU - Kirschning, Andreas

AU - Müller, Rolf

PY - 2011/12/23

Y1 - 2011/12/23

N2 - Joint efforts: The antifungal icumazole A, the potassium-ion-channel inhibitor noricumazole A, and their glycosylated derivatives are new, structurally related secondary metabolites isolated from Sorangium cellulosum. Their structures have been fully assigned by a joint strategy that relied on spectroscopy, derivatization, fragmentation, and finally the first total synthesis of noricumazole A.

AB - Joint efforts: The antifungal icumazole A, the potassium-ion-channel inhibitor noricumazole A, and their glycosylated derivatives are new, structurally related secondary metabolites isolated from Sorangium cellulosum. Their structures have been fully assigned by a joint strategy that relied on spectroscopy, derivatization, fragmentation, and finally the first total synthesis of noricumazole A.

KW - antibiotics

KW - ion-channel inhibitors

KW - myxobacteria

KW - natural products

KW - structure elucidation

KW - total synthesis

UR - http://www.scopus.com/inward/record.url?scp=84856159568&partnerID=8YFLogxK

U2 - 10.1002/anie.201106435

DO - 10.1002/anie.201106435

M3 - Article

C2 - 22213143

AN - SCOPUS:84856159568

VL - 51

SP - 1256

EP - 1260

JO - Angewandte Chemie

JF - Angewandte Chemie

SN - 1433-7851

IS - 5

ER -

Von denselben Autoren