Implementation of a modular digital laboratory infrastructure for SiLA 2 based devices

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OriginalspracheEnglisch
Aufsatznummer100380
FachzeitschriftSLAS Technology
Jahrgang36
Frühes Online-Datum4 Dez. 2025
PublikationsstatusVeröffentlicht - Jan. 2026

Abstract

Laboratory digitalization is a complex field that includes many aspects to consider, such as device control, data management, and data evaluation. This article presents a potential laboratory digitalization process, including the use of open-source software and hardware components from laboratory equipment to data evaluation. It shows what is required and how it can be used. In this example, a SiLA-based continuous chromatography system is used as a model device to demonstrate the possible purification of GFP from crude cell lysate. The current version of the Gateway Module is a translation unit for driver protocols used for device control. It uses SiLA-based drivers within a Docker environment to communicate with the server infrastructure. The Gateway Module software was managed and rolled out with the mkbox-project. Finally, the recorded laboratory data are stored in a data management system and made available for later analysis. The article also discusses how software and hardware are maintained in the background, as well as the update strategy used.

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Implementation of a modular digital laboratory infrastructure for SiLA 2 based devices. / Lange, Ferdinand; Habich, Tessa; Beutel, Sascha.
in: SLAS Technology, Jahrgang 36, 100380, 01.2026.

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Lange F, Habich T, Beutel S. Implementation of a modular digital laboratory infrastructure for SiLA 2 based devices. SLAS Technology. 2026 Jan;36:100380. Epub 2025 Dez 4. doi: 10.1016/j.slast.2025.100380
Lange, Ferdinand ; Habich, Tessa ; Beutel, Sascha. / Implementation of a modular digital laboratory infrastructure for SiLA 2 based devices. in: SLAS Technology. 2026 ; Jahrgang 36.
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