TY - JOUR

T1 - Human Amniotic Membrane

T2 - A review on tissue engineering, application, and storage

AU - Leal-Marin, Sara

AU - Kern, Thomas

AU - Hofmann, Nicola

AU - Pogozhykh, Olena

AU - Framme, Carsten

AU - Borgel, Martin

AU - Figueiredo, Constanca

AU - Glasmacher, Birgit

AU - Gryshkov, Oleksandr

N1 - Funding Information: This work was in part funded by the German Academic Exchange Service (DAAD, 91725466) in the framework of the Research Grants ‐ Doctoral programs in Germany. Open access funding enabled and organized by Projekt DEAL.

PY - 2021/6/12

Y1 - 2021/6/12

N2 - Human amniotic membrane (hAM) has been employed as scaffolding material in a wide range of tissue engineering applications, especially as a skin dressing and as a graft for corneal treatment, due to the structure of the extracellular matrix and excellent biological properties that enhance both wound healing and tissue regeneration. This review highlights recent work and current knowledge on the application of native hAM, and/or production of hAM-based tissue-engineered products to create scaffolds mimicking the structure of the native membrane to enhance the hAM performance. Moreover, an overview is presented on the available (cryo) preservation techniques for storage of native hAM and tissue-engineered products that are necessary to maintain biological functions such as angiogenesis, anti-inflammation, antifibrotic and antibacterial activity.

AB - Human amniotic membrane (hAM) has been employed as scaffolding material in a wide range of tissue engineering applications, especially as a skin dressing and as a graft for corneal treatment, due to the structure of the extracellular matrix and excellent biological properties that enhance both wound healing and tissue regeneration. This review highlights recent work and current knowledge on the application of native hAM, and/or production of hAM-based tissue-engineered products to create scaffolds mimicking the structure of the native membrane to enhance the hAM performance. Moreover, an overview is presented on the available (cryo) preservation techniques for storage of native hAM and tissue-engineered products that are necessary to maintain biological functions such as angiogenesis, anti-inflammation, antifibrotic and antibacterial activity.

KW - cryopreservation

KW - cryoprotective agent (CPA)

KW - extracellular matrix (ECM)

KW - human amniotic membrane (hAM)

KW - scaffold

KW - tissue engineering (TE)

UR - http://www.scopus.com/inward/record.url?scp=85105484664&partnerID=8YFLogxK

U2 - 10.1002/jbm.b.34782

DO - 10.1002/jbm.b.34782

M3 - Review article

VL - 109

SP - 1198

EP - 1215

JO - Journal of Biomedical Materials Research - Part B Applied Biomaterials

JF - Journal of Biomedical Materials Research - Part B Applied Biomaterials

SN - 1552-4973

IS - 8

ER -