Fermentation-based valorization of agro-industrial cereal wastes and by-products

Publikation: Beitrag in FachzeitschriftÜbersichtsarbeitForschungPeer-Review

Autorschaft

  • Muhammad Zeeshan Adil
  • Sebahat Oztekin
  • Afifa Aziz
  • Deniz Gunal-Koroglu
  • Esra Capanoglu
  • Andres Moreno
  • Waseem Khalid
  • Tuba Esatbeyoglu

Externe Organisationen

  • South China University of Technology
  • Ataturk University
  • İstanbul Teknik Üniversitesi (İTÜ)
  • Universität Kastilien-La Mancha
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Details

OriginalspracheEnglisch
Aufsatznummer105464
FachzeitschriftTrends in Food Science and Technology
Jahrgang168
Frühes Online-Datum3 Dez. 2025
PublikationsstatusVeröffentlicht - Feb. 2026

Abstract

Background: Agro-industrial cereal processing generates large volumes of nutrient-rich by-products such as bran, husks, and spent grains that remain underutilized. These residues contain proteins, fibers, phenolics, and micronutrients that can be efficiently recovered through sustainable bioprocessing. Scope and approach: This review synthesizes recent advances in fermentation-based valorization of cereal waste and by-products, focusing on solid-state and submerged systems involving bacteria, fungi, and yeasts. It uniquely integrates microbial fermentation strategies with sustainability and examines their compositional enhancement, bioactive compound release, and antinutrient reduction. It also highlights emerging developments such as AI- and ML-assisted fermentation process optimization, which aligns cereal waste valorization with SDGs and next-generation bioprocess design. Key findings and conclusions: Fermentation enhances protein digestibility, phenolic bioaccessibility, and prebiotic oligosaccharide yield, while reducing phytic acid, tannins, and mycotoxins. Pretreatment, followed by fermentation, enhances nutrient release and improves the functional properties of bran, husks, and spent grains. These improvements support industrial applications range from functional foods and nutraceuticals to biofuels and bioplastics. However, scalability remains constrained by substrate variability, process optimization challanges, and economic feasibility. Integrating multi-omics datasets, adaptive biorefinery models, and AI-based control systems could accelerate the transition toward sustainable, data-driven cereal waste valorization, establishing fermentation as a cornerstone technology linking waste reduction, functional food innovation, and the global sustainability agenda.

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Fermentation-based valorization of agro-industrial cereal wastes and by-products. / Adil, Muhammad Zeeshan; Oztekin, Sebahat; Aziz, Afifa et al.
in: Trends in Food Science and Technology, Jahrgang 168, 105464, 02.2026.

Publikation: Beitrag in FachzeitschriftÜbersichtsarbeitForschungPeer-Review

Adil MZ, Oztekin S, Aziz A, Gunal-Koroglu D, Capanoglu E, Moreno A et al. Fermentation-based valorization of agro-industrial cereal wastes and by-products. Trends in Food Science and Technology. 2026 Feb;168:105464. Epub 2025 Dez 3. doi: 10.1016/j.tifs.2025.105464, 10.1016/j.tifs.2025.105464
Adil, Muhammad Zeeshan ; Oztekin, Sebahat ; Aziz, Afifa et al. / Fermentation-based valorization of agro-industrial cereal wastes and by-products. in: Trends in Food Science and Technology. 2026 ; Jahrgang 168.
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AU - Adil, Muhammad Zeeshan

AU - Oztekin, Sebahat

AU - Aziz, Afifa

AU - Gunal-Koroglu, Deniz

AU - Capanoglu, Esra

AU - Moreno, Andres

AU - Khalid, Waseem

AU - Esatbeyoglu, Tuba

N1 - Publisher Copyright: © 2025 The Authors

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N2 - Background: Agro-industrial cereal processing generates large volumes of nutrient-rich by-products such as bran, husks, and spent grains that remain underutilized. These residues contain proteins, fibers, phenolics, and micronutrients that can be efficiently recovered through sustainable bioprocessing. Scope and approach: This review synthesizes recent advances in fermentation-based valorization of cereal waste and by-products, focusing on solid-state and submerged systems involving bacteria, fungi, and yeasts. It uniquely integrates microbial fermentation strategies with sustainability and examines their compositional enhancement, bioactive compound release, and antinutrient reduction. It also highlights emerging developments such as AI- and ML-assisted fermentation process optimization, which aligns cereal waste valorization with SDGs and next-generation bioprocess design. Key findings and conclusions: Fermentation enhances protein digestibility, phenolic bioaccessibility, and prebiotic oligosaccharide yield, while reducing phytic acid, tannins, and mycotoxins. Pretreatment, followed by fermentation, enhances nutrient release and improves the functional properties of bran, husks, and spent grains. These improvements support industrial applications range from functional foods and nutraceuticals to biofuels and bioplastics. However, scalability remains constrained by substrate variability, process optimization challanges, and economic feasibility. Integrating multi-omics datasets, adaptive biorefinery models, and AI-based control systems could accelerate the transition toward sustainable, data-driven cereal waste valorization, establishing fermentation as a cornerstone technology linking waste reduction, functional food innovation, and the global sustainability agenda.

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KW - Cereal residues

KW - Circular bioeconomy

KW - Machine learning

KW - Solid-state fermentation (SSF)

KW - Sustainable development goals

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SN - 0924-2244

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ER -

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