Elansolid A3, a unique p-quinone methide antibiotic from Chitinophaga sancti

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Autorschaft

  • Rolf Jansen
  • Klaus Gerth
  • Heinrich Steinmetz
  • Silke Reinecke
  • Wolfgang Kessler
  • Andreas Kirschning
  • Rolf Müller

Externe Organisationen

  • Helmholtz-Zentrum für Infektionsforschung GmbH (HZI)
  • Universität des Saarlandes
Forschungs-netzwerk anzeigen

Details

OriginalspracheEnglisch
Seiten (von - bis)7739-7744
Seitenumfang6
FachzeitschriftChemistry - A European Journal
Jahrgang17
Ausgabenummer28
PublikationsstatusVeröffentlicht - 30 Mai 2011

Abstract

Hen or egg? The polyketide-based p-quinone methide antibiotic, elansolid A3, was isolated from the gliding bacterium Chitinophaga sancti. It now appears probable that elansolid A3 is the underlying biosynthetic product of the atropisomeric macrolide antibiotics elansolid A1 and A2 (see scheme). Under mild basic conditions the interconversion of elansolid isomers A1-A3 was observed. Under mild acidic conditions a Grob-type fragmentation of elansolid A3 led to the p-hydroxy styryl isomer elansolid D.

ASJC Scopus Sachgebiete

Zitieren

Elansolid A3, a unique p-quinone methide antibiotic from Chitinophaga sancti. / Jansen, Rolf; Gerth, Klaus; Steinmetz, Heinrich et al.
in: Chemistry - A European Journal, Jahrgang 17, Nr. 28, 30.05.2011, S. 7739-7744.

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Jansen, R, Gerth, K, Steinmetz, H, Reinecke, S, Kessler, W, Kirschning, A & Müller, R 2011, 'Elansolid A3, a unique p-quinone methide antibiotic from Chitinophaga sancti', Chemistry - A European Journal, Jg. 17, Nr. 28, S. 7739-7744. https://doi.org/10.1002/chem.201100457
Jansen, R., Gerth, K., Steinmetz, H., Reinecke, S., Kessler, W., Kirschning, A., & Müller, R. (2011). Elansolid A3, a unique p-quinone methide antibiotic from Chitinophaga sancti. Chemistry - A European Journal, 17(28), 7739-7744. https://doi.org/10.1002/chem.201100457
Jansen R, Gerth K, Steinmetz H, Reinecke S, Kessler W, Kirschning A et al. Elansolid A3, a unique p-quinone methide antibiotic from Chitinophaga sancti. Chemistry - A European Journal. 2011 Mai 30;17(28):7739-7744. doi: 10.1002/chem.201100457
Jansen, Rolf ; Gerth, Klaus ; Steinmetz, Heinrich et al. / Elansolid A3, a unique p-quinone methide antibiotic from Chitinophaga sancti. in: Chemistry - A European Journal. 2011 ; Jahrgang 17, Nr. 28. S. 7739-7744.
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AU - Gerth, Klaus

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AU - Reinecke, Silke

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AU - Kirschning, Andreas

AU - Müller, Rolf

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