Details
| Originalsprache | Englisch |
|---|---|
| Aufsatznummer | 200346 |
| Fachzeitschrift | Human Nutrition and Metabolism |
| Jahrgang | 42 |
| Frühes Online-Datum | 25 Sept. 2025 |
| Publikationsstatus | Veröffentlicht - Dez. 2025 |
Abstract
Metabolic syndrome (MetS) is characterized by a cluster of metabolic disturbances, including elevated triglyceride (TAG) levels, obesity, and hypertension, and is associated with an increased risk of coronary heart disease and type 2 diabetes mellitus. Dietary interventions involving L-arginine (L-Arg), L-citrulline (L-Cit) and micronutrients may support numerous physiological functions and improve health during metabolic disturbances. We hypothesized that L-Arg, L-Cit, and micronutrient supplementation decreases elevated TAG levels (≥150 mg/dL) and improves metabolic health. This proof-of-principle study was an eight-week randomized double-blind intervention involving 60 obese individuals (age: 59.9 ± 7.5 years, BMI: 33.6 ± 4.7 kg/m2, TAG level: 211 ± 71.2 mg/dL). The study aimed to investigate the potential effects of L-Arg, L-Cit, and micronutrient supplementation on TAG levels and the MetS severity score based on waist circumference (WC). After eight-weeks of supplementation, the verum group showed a significant decrease in TAG levels compared to placebo (p < 0.001), and significant reductions in LDL-C (p = 0.038), systolic blood pressure (BP) (p = 0.040), and body fat mass (p = 0.045). In contrast, no effects were observed on fasting glucose, WC or diastolic BP. Participants in the verum group showed a significant decrease in the MetS severity score (p = 0.041), suggesting an improvement in metabolic health, while those in the placebo group showed no changes. This proof-of-principle study indicate that L-Arg, L-Cit, and micronutrient supplementation may reduce TAG levels and potentially improve overall metabolic health in obese individuals with elevated TAG. Confirmatory studies are needed to substantiate these exploratory findings.
ASJC Scopus Sachgebiete
- Medizin (insg.)
- Endokrinologie, Diabetes und Stoffwechsel
- Agrar- und Biowissenschaften (insg.)
- Lebensmittelwissenschaften
- Pflege (insg.)
- Ernährung und Diätetik
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in: Human Nutrition and Metabolism, Jahrgang 42, 200346, 12.2025.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Effect of L-arginine, L-citrulline and micronutrient supplementation on elevated triglyceride levels and metabolic syndrome severity score
AU - Kerlikowsky, Felix
AU - Hahn, Andreas
N1 - Publisher Copyright: © 2025 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license. http://creativecommons.org/licenses/by/4.0/
PY - 2025/12
Y1 - 2025/12
N2 - Metabolic syndrome (MetS) is characterized by a cluster of metabolic disturbances, including elevated triglyceride (TAG) levels, obesity, and hypertension, and is associated with an increased risk of coronary heart disease and type 2 diabetes mellitus. Dietary interventions involving L-arginine (L-Arg), L-citrulline (L-Cit) and micronutrients may support numerous physiological functions and improve health during metabolic disturbances. We hypothesized that L-Arg, L-Cit, and micronutrient supplementation decreases elevated TAG levels (≥150 mg/dL) and improves metabolic health. This proof-of-principle study was an eight-week randomized double-blind intervention involving 60 obese individuals (age: 59.9 ± 7.5 years, BMI: 33.6 ± 4.7 kg/m2, TAG level: 211 ± 71.2 mg/dL). The study aimed to investigate the potential effects of L-Arg, L-Cit, and micronutrient supplementation on TAG levels and the MetS severity score based on waist circumference (WC). After eight-weeks of supplementation, the verum group showed a significant decrease in TAG levels compared to placebo (p < 0.001), and significant reductions in LDL-C (p = 0.038), systolic blood pressure (BP) (p = 0.040), and body fat mass (p = 0.045). In contrast, no effects were observed on fasting glucose, WC or diastolic BP. Participants in the verum group showed a significant decrease in the MetS severity score (p = 0.041), suggesting an improvement in metabolic health, while those in the placebo group showed no changes. This proof-of-principle study indicate that L-Arg, L-Cit, and micronutrient supplementation may reduce TAG levels and potentially improve overall metabolic health in obese individuals with elevated TAG. Confirmatory studies are needed to substantiate these exploratory findings.
AB - Metabolic syndrome (MetS) is characterized by a cluster of metabolic disturbances, including elevated triglyceride (TAG) levels, obesity, and hypertension, and is associated with an increased risk of coronary heart disease and type 2 diabetes mellitus. Dietary interventions involving L-arginine (L-Arg), L-citrulline (L-Cit) and micronutrients may support numerous physiological functions and improve health during metabolic disturbances. We hypothesized that L-Arg, L-Cit, and micronutrient supplementation decreases elevated TAG levels (≥150 mg/dL) and improves metabolic health. This proof-of-principle study was an eight-week randomized double-blind intervention involving 60 obese individuals (age: 59.9 ± 7.5 years, BMI: 33.6 ± 4.7 kg/m2, TAG level: 211 ± 71.2 mg/dL). The study aimed to investigate the potential effects of L-Arg, L-Cit, and micronutrient supplementation on TAG levels and the MetS severity score based on waist circumference (WC). After eight-weeks of supplementation, the verum group showed a significant decrease in TAG levels compared to placebo (p < 0.001), and significant reductions in LDL-C (p = 0.038), systolic blood pressure (BP) (p = 0.040), and body fat mass (p = 0.045). In contrast, no effects were observed on fasting glucose, WC or diastolic BP. Participants in the verum group showed a significant decrease in the MetS severity score (p = 0.041), suggesting an improvement in metabolic health, while those in the placebo group showed no changes. This proof-of-principle study indicate that L-Arg, L-Cit, and micronutrient supplementation may reduce TAG levels and potentially improve overall metabolic health in obese individuals with elevated TAG. Confirmatory studies are needed to substantiate these exploratory findings.
KW - Hypertriglyceridemia
KW - L-arginine and L-citrulline supplementation
KW - Metabolic syndrome severity score
KW - Micronutrient supplementation
UR - http://www.scopus.com/inward/record.url?scp=105018086944&partnerID=8YFLogxK
U2 - 10.1016/j.hnm.2025.200346
DO - 10.1016/j.hnm.2025.200346
M3 - Article
AN - SCOPUS:105018086944
VL - 42
JO - Human Nutrition and Metabolism
JF - Human Nutrition and Metabolism
M1 - 200346
ER -