Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 1413-1418 |
| Seitenumfang | 6 |
| Fachzeitschrift | Tetrahedron |
| Jahrgang | 71 |
| Ausgabenummer | 9 |
| Publikationsstatus | Veröffentlicht - 15 Jan. 2015 |
Abstract
Azaenamine incorporating pyrazole-4-carboxylate is prepared and allowed to react with α,β-substituted nitriles. A new reactivity pattern was observed leading to the formation of substituted pyrazolo[4′,3′-5,6]pyrimido[2,1-a]phthalazine-9-carbonitriles, which can be considered as aromatic aza-steroid analogues.
ASJC Scopus Sachgebiete
- Biochemie, Genetik und Molekularbiologie (insg.)
- Biochemie
- Pharmakologie, Toxikologie und Pharmazie (insg.)
- Wirkstoffforschung
- Chemie (insg.)
- Organische Chemie
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in: Tetrahedron, Jahrgang 71, Nr. 9, 15.01.2015, S. 1413-1418.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Discrepancies in the reactivity pattern of azaenamines towards cinnamonitriles
T2 - Synthesis of novel aza-steroid analogues
AU - Ghozlan, Said A.S.
AU - Abdelmoniem, Amr M.
AU - Butenschön, Holger
AU - Abdelhamid, Ismail A.
N1 - Funding Information: Ismail Abdelshafy Abdelhamid and Amr Mohamed Abdelmoniem gratefully acknowledge postdoctoral fellowships by the Alexander von Humboldt foundation (AvH). Publisher Copyright: © 2015 Elsevier Ltd. All rights reserved. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.
PY - 2015/1/15
Y1 - 2015/1/15
N2 - Azaenamine incorporating pyrazole-4-carboxylate is prepared and allowed to react with α,β-substituted nitriles. A new reactivity pattern was observed leading to the formation of substituted pyrazolo[4′,3′-5,6]pyrimido[2,1-a]phthalazine-9-carbonitriles, which can be considered as aromatic aza-steroid analogues.
AB - Azaenamine incorporating pyrazole-4-carboxylate is prepared and allowed to react with α,β-substituted nitriles. A new reactivity pattern was observed leading to the formation of substituted pyrazolo[4′,3′-5,6]pyrimido[2,1-a]phthalazine-9-carbonitriles, which can be considered as aromatic aza-steroid analogues.
KW - Azaenamine
KW - Michael addition
KW - New reactivity pattern
KW - Steroidal phenanthrenes
KW - α,β-Substituted nitriles
UR - http://www.scopus.com/inward/record.url?scp=84922753938&partnerID=8YFLogxK
U2 - 10.1016/j.tet.2015.01.026
DO - 10.1016/j.tet.2015.01.026
M3 - Article
AN - SCOPUS:84922753938
VL - 71
SP - 1413
EP - 1418
JO - Tetrahedron
JF - Tetrahedron
SN - 0040-4020
IS - 9
ER -