Concentric and eccentric endurance exercise reverse hallmarks of T cell senescence in pre-diabetic subjects

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Autorschaft

  • Marc Philippe
  • Martin Burtscher
  • Birgit Weinberger
  • Michael Keller
  • Beatrix Grubeck-Loebenstein
  • Johannes Fleckenstein
  • Katharina Alack
  • K. Krüger

Organisationseinheiten

Externe Organisationen

  • Justus-Liebig-Universität Gießen
  • Universität Innsbruck
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Details

OriginalspracheEnglisch
Aufsatznummer684
Seitenumfang8
FachzeitschriftFrontiers in psychology
Jahrgang10
AusgabenummerJUN
PublikationsstatusVeröffentlicht - 4 Juni 2019

Abstract

The peripheral T-cell pool undergoes a striking age associated remodeling which is accelerated by progressive insulin resistance. Exercise training is known to delay several aspects of T-cell senescence. The purpose of the current study was to investigate the effect of 3 weeks regular concentric or eccentric endurance exercise training on the composition of the T-cell compartment in pre-diabetic subjects. Sixteen male older adults with impaired glucose tolerance were recruited and performed either concentric exercise (CE) or eccentric exercise (EE) walking 3 times a week for 3 weeks. Fasting venous blood sampling was performed before training and after the training intervention. Various T-cell subpopulations were analyzed by flow cytometry. We did not find significant time × group effects (interaction) but found several significant time effects for cell type ratios and cell subsets proportions. There was an increase of the CD4+/CD8+ (0.55 ± 0.85%; p = 0.033) and CD4+/CD3+ ratio (5.63 ± 8.44%; p = 0.018) and a decrease of the CD8+/CD3+ ratio (-0.95 ± 1.64%; p = 0.049) after training. We found proportional increases of CD4+/CCR7+/CD45RO+ central memory cells (5.02 ± 7.68%; p = 0.030), naïve CD8+/CCR7+/CD45RO- (3.00 ± 6.68%; p = 0.047) and CD8+/CCR7+/CD45RO+ central memory cells (3.01 ± 3.70%; p = 0.009), while proportions of CD4+/CCR7-/CD45RO- TEMRA cells (-2.17 ± 4.66%; p = 0.012), CD8+/CCR7-/CD45RO- TEMRA cells (-5.11 ± 7.02%; p = 0.018) and CD16+ cells (-4.67 ± 6.45%; p = 0.016) decreased after training. 3 weeks of either CE or EE were effective in reversing hallmarks of T-cell senescence in pre-diabetic subjects. It is suggested that exercise stimulates production and mobilization of naïve T-cells, while differentiated TEMRA cells might disappear by apoptosis.

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Concentric and eccentric endurance exercise reverse hallmarks of T cell senescence in pre-diabetic subjects. / Philippe, Marc; Burtscher, Martin ; Weinberger, Birgit et al.
in: Frontiers in psychology, Jahrgang 10, Nr. JUN, 684, 04.06.2019.

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Philippe, M, Burtscher, M, Weinberger, B, Keller, M, Grubeck-Loebenstein, B, Fleckenstein, J, Alack, K & Krüger, K 2019, 'Concentric and eccentric endurance exercise reverse hallmarks of T cell senescence in pre-diabetic subjects', Frontiers in psychology, Jg. 10, Nr. JUN, 684. https://doi.org/10.3389/fphys.2019.00684
Philippe, M., Burtscher, M., Weinberger, B., Keller, M., Grubeck-Loebenstein, B., Fleckenstein, J., Alack, K., & Krüger, K. (2019). Concentric and eccentric endurance exercise reverse hallmarks of T cell senescence in pre-diabetic subjects. Frontiers in psychology, 10(JUN), Artikel 684. https://doi.org/10.3389/fphys.2019.00684
Philippe M, Burtscher M, Weinberger B, Keller M, Grubeck-Loebenstein B, Fleckenstein J et al. Concentric and eccentric endurance exercise reverse hallmarks of T cell senescence in pre-diabetic subjects. Frontiers in psychology. 2019 Jun 4;10(JUN):684. doi: 10.3389/fphys.2019.00684
Philippe, Marc ; Burtscher, Martin ; Weinberger, Birgit et al. / Concentric and eccentric endurance exercise reverse hallmarks of T cell senescence in pre-diabetic subjects. in: Frontiers in psychology. 2019 ; Jahrgang 10, Nr. JUN.
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title = "Concentric and eccentric endurance exercise reverse hallmarks of T cell senescence in pre-diabetic subjects",
abstract = "The peripheral T-cell pool undergoes a striking age associated remodeling which is accelerated by progressive insulin resistance. Exercise training is known to delay several aspects of T-cell senescence. The purpose of the current study was to investigate the effect of 3 weeks regular concentric or eccentric endurance exercise training on the composition of the T-cell compartment in pre-diabetic subjects. Sixteen male older adults with impaired glucose tolerance were recruited and performed either concentric exercise (CE) or eccentric exercise (EE) walking 3 times a week for 3 weeks. Fasting venous blood sampling was performed before training and after the training intervention. Various T-cell subpopulations were analyzed by flow cytometry. We did not find significant time × group effects (interaction) but found several significant time effects for cell type ratios and cell subsets proportions. There was an increase of the CD4+/CD8+ (0.55 ± 0.85%; p = 0.033) and CD4+/CD3+ ratio (5.63 ± 8.44%; p = 0.018) and a decrease of the CD8+/CD3+ ratio (-0.95 ± 1.64%; p = 0.049) after training. We found proportional increases of CD4+/CCR7+/CD45RO+ central memory cells (5.02 ± 7.68%; p = 0.030), na{\"i}ve CD8+/CCR7+/CD45RO- (3.00 ± 6.68%; p = 0.047) and CD8+/CCR7+/CD45RO+ central memory cells (3.01 ± 3.70%; p = 0.009), while proportions of CD4+/CCR7-/CD45RO- TEMRA cells (-2.17 ± 4.66%; p = 0.012), CD8+/CCR7-/CD45RO- TEMRA cells (-5.11 ± 7.02%; p = 0.018) and CD16+ cells (-4.67 ± 6.45%; p = 0.016) decreased after training. 3 weeks of either CE or EE were effective in reversing hallmarks of T-cell senescence in pre-diabetic subjects. It is suggested that exercise stimulates production and mobilization of na{\"i}ve T-cells, while differentiated TEMRA cells might disappear by apoptosis.",
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author = "Marc Philippe and Martin Burtscher and Birgit Weinberger and Michael Keller and Beatrix Grubeck-Loebenstein and Johannes Fleckenstein and Katharina Alack and K. Kr{\"u}ger",
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Download

TY - JOUR

T1 - Concentric and eccentric endurance exercise reverse hallmarks of T cell senescence in pre-diabetic subjects

AU - Philippe, Marc

AU - Burtscher, Martin

AU - Weinberger, Birgit

AU - Keller, Michael

AU - Grubeck-Loebenstein, Beatrix

AU - Fleckenstein, Johannes

AU - Alack, Katharina

AU - Krüger, K.

N1 - Funding Information: This study was supported by the National Research Fund, Luxembourg (AFR Ph.D. Grant 4919742).

PY - 2019/6/4

Y1 - 2019/6/4

N2 - The peripheral T-cell pool undergoes a striking age associated remodeling which is accelerated by progressive insulin resistance. Exercise training is known to delay several aspects of T-cell senescence. The purpose of the current study was to investigate the effect of 3 weeks regular concentric or eccentric endurance exercise training on the composition of the T-cell compartment in pre-diabetic subjects. Sixteen male older adults with impaired glucose tolerance were recruited and performed either concentric exercise (CE) or eccentric exercise (EE) walking 3 times a week for 3 weeks. Fasting venous blood sampling was performed before training and after the training intervention. Various T-cell subpopulations were analyzed by flow cytometry. We did not find significant time × group effects (interaction) but found several significant time effects for cell type ratios and cell subsets proportions. There was an increase of the CD4+/CD8+ (0.55 ± 0.85%; p = 0.033) and CD4+/CD3+ ratio (5.63 ± 8.44%; p = 0.018) and a decrease of the CD8+/CD3+ ratio (-0.95 ± 1.64%; p = 0.049) after training. We found proportional increases of CD4+/CCR7+/CD45RO+ central memory cells (5.02 ± 7.68%; p = 0.030), naïve CD8+/CCR7+/CD45RO- (3.00 ± 6.68%; p = 0.047) and CD8+/CCR7+/CD45RO+ central memory cells (3.01 ± 3.70%; p = 0.009), while proportions of CD4+/CCR7-/CD45RO- TEMRA cells (-2.17 ± 4.66%; p = 0.012), CD8+/CCR7-/CD45RO- TEMRA cells (-5.11 ± 7.02%; p = 0.018) and CD16+ cells (-4.67 ± 6.45%; p = 0.016) decreased after training. 3 weeks of either CE or EE were effective in reversing hallmarks of T-cell senescence in pre-diabetic subjects. It is suggested that exercise stimulates production and mobilization of naïve T-cells, while differentiated TEMRA cells might disappear by apoptosis.

AB - The peripheral T-cell pool undergoes a striking age associated remodeling which is accelerated by progressive insulin resistance. Exercise training is known to delay several aspects of T-cell senescence. The purpose of the current study was to investigate the effect of 3 weeks regular concentric or eccentric endurance exercise training on the composition of the T-cell compartment in pre-diabetic subjects. Sixteen male older adults with impaired glucose tolerance were recruited and performed either concentric exercise (CE) or eccentric exercise (EE) walking 3 times a week for 3 weeks. Fasting venous blood sampling was performed before training and after the training intervention. Various T-cell subpopulations were analyzed by flow cytometry. We did not find significant time × group effects (interaction) but found several significant time effects for cell type ratios and cell subsets proportions. There was an increase of the CD4+/CD8+ (0.55 ± 0.85%; p = 0.033) and CD4+/CD3+ ratio (5.63 ± 8.44%; p = 0.018) and a decrease of the CD8+/CD3+ ratio (-0.95 ± 1.64%; p = 0.049) after training. We found proportional increases of CD4+/CCR7+/CD45RO+ central memory cells (5.02 ± 7.68%; p = 0.030), naïve CD8+/CCR7+/CD45RO- (3.00 ± 6.68%; p = 0.047) and CD8+/CCR7+/CD45RO+ central memory cells (3.01 ± 3.70%; p = 0.009), while proportions of CD4+/CCR7-/CD45RO- TEMRA cells (-2.17 ± 4.66%; p = 0.012), CD8+/CCR7-/CD45RO- TEMRA cells (-5.11 ± 7.02%; p = 0.018) and CD16+ cells (-4.67 ± 6.45%; p = 0.016) decreased after training. 3 weeks of either CE or EE were effective in reversing hallmarks of T-cell senescence in pre-diabetic subjects. It is suggested that exercise stimulates production and mobilization of naïve T-cells, while differentiated TEMRA cells might disappear by apoptosis.

KW - Concentric exercise

KW - Eccentric exercise

KW - Inflammation

KW - Naïve T-cells

KW - TEMRA cells

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U2 - 10.3389/fphys.2019.00684

DO - 10.3389/fphys.2019.00684

M3 - Article

VL - 10

JO - Frontiers in psychology

JF - Frontiers in psychology

SN - 1664-1078

IS - JUN

M1 - 684

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