Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 27-29 |
| Seitenumfang | 3 |
| Fachzeitschrift | CHEMBIOCHEM |
| Jahrgang | 15 |
| Ausgabenummer | 1 |
| Publikationsstatus | Veröffentlicht - 3 Jan. 2014 |
Abstract
The PKS tree gets a new branch: Hertweck and co-workers have uncovered the enzymology behind the novel β-branching strategy used during Rhizoxin biosynthesis in Burholderia rhizoxinica. Both the KS and B domains are required for a δ-lactone to form by attack on the pre-existing polyketide chain; further chain extension must occur on the newly added β-branching carbonyl.
ASJC Scopus Sachgebiete
- Biochemie, Genetik und Molekularbiologie (insg.)
- Biochemie
- Biochemie, Genetik und Molekularbiologie (insg.)
- Molekularmedizin
- Biochemie, Genetik und Molekularbiologie (insg.)
- Molekularbiologie
- Chemie (insg.)
- Organische Chemie
Zitieren
- Standard
- Harvard
- Apa
- Vancouver
- BibTex
- RIS
in: CHEMBIOCHEM, Jahrgang 15, Nr. 1, 03.01.2014, S. 27-29.
Publikation: Beitrag in Fachzeitschrift › Übersichtsarbeit › Forschung › Peer-Review
}
TY - JOUR
T1 - β-Chain extension
T2 - A new mode of carbon-carbon bond formation and chain extension by polyketide synthases
AU - Cox, Russell J.
PY - 2014/1/3
Y1 - 2014/1/3
N2 - The PKS tree gets a new branch: Hertweck and co-workers have uncovered the enzymology behind the novel β-branching strategy used during Rhizoxin biosynthesis in Burholderia rhizoxinica. Both the KS and B domains are required for a δ-lactone to form by attack on the pre-existing polyketide chain; further chain extension must occur on the newly added β-branching carbonyl.
AB - The PKS tree gets a new branch: Hertweck and co-workers have uncovered the enzymology behind the novel β-branching strategy used during Rhizoxin biosynthesis in Burholderia rhizoxinica. Both the KS and B domains are required for a δ-lactone to form by attack on the pre-existing polyketide chain; further chain extension must occur on the newly added β-branching carbonyl.
KW - biosynthesis
KW - branching
KW - polyketides
KW - rhizoxin
UR - http://www.scopus.com/inward/record.url?scp=84890800202&partnerID=8YFLogxK
U2 - 10.1002/cbic.201300660
DO - 10.1002/cbic.201300660
M3 - Review article
C2 - 24222633
AN - SCOPUS:84890800202
VL - 15
SP - 27
EP - 29
JO - CHEMBIOCHEM
JF - CHEMBIOCHEM
SN - 1439-4227
IS - 1
ER -