A practical synthesis of Rho-Kinase inhibitor Y-27632 and fluoro derivatives and their evaluation in human pluripotent stem cells

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

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OriginalspracheEnglisch
Seiten (von - bis)5503-5510
Seitenumfang8
FachzeitschriftOrganic and Biomolecular Chemistry
Jahrgang9
Ausgabenummer15
PublikationsstatusVeröffentlicht - 7 Aug. 2011

Abstract

A practical synthesis of the Rho-Kinase inhibitor Y-27632 and two new fluoro derivatives was achieved in seven steps and with a good overall yield of 45% starting from commercially available (R)-1-phenylethylamine. Compared to Y-27632 the new fluoro derivatives showed reduced or no effect on hPSC vitality and expansion after dissociation in human pluripotent stem cells.

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A practical synthesis of Rho-Kinase inhibitor Y-27632 and fluoro derivatives and their evaluation in human pluripotent stem cells. / Paleek, Jií; Zweigerdt, Robert; Olmer, Ruth et al.
in: Organic and Biomolecular Chemistry, Jahrgang 9, Nr. 15, 07.08.2011, S. 5503-5510.

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

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AU - Dräger, Gerald

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