Details
| Originalsprache | Englisch |
|---|---|
| Aufsatznummer | 465923 |
| Fachzeitschrift | Journal of Chromatography A |
| Jahrgang | 1750 |
| Frühes Online-Datum | 29 März 2025 |
| Publikationsstatus | Veröffentlicht - 7 Juni 2025 |
Abstract
For higher analytical performance, ion mobility spectrometers (IMS), especially when analyzing complex mixtures, are often coupled with gas chromatographs (GC). However, analysis time remains a critical parameter in gas chromatography. Therefore, a hyper-fast GC is a promising approach for GC-IMS to combine highest sensitivity of IMS with increased peak capacity while allowing for rapid analysis within the double-digit second range. For simultaneously recording of both ion polarities, a new dual drift tube IMS in axial configuration has been developed that is particularly designed for resolving even hyper-fast GC peaks. Key is a directed sample gas flow through the ionization region giving a small effective detector volume. To avoid condensation of the sample gas, the IMS is isothermally heated to 120 °C. A drift tube length of only LD = 41 mm with a drift voltage of UD = 2.7 kV leads to an IMS repetition rate of 100 Hz and high resolving power of Rp = 60, even for ions with low reduced ion mobility down to 0.43 cm2V-1s-1. This setup can resolve very short GC peaks with full width at half maximum of only 140 ms. For demonstration, two different hop varieties and a mixture of explosives were analyzed within a short time of just 20 s.
ASJC Scopus Sachgebiete
- Chemie (insg.)
- Analytische Chemie
- Biochemie, Genetik und Molekularbiologie (insg.)
- Biochemie
- Chemie (insg.)
- Organische Chemie
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in: Journal of Chromatography A, Jahrgang 1750, 465923, 07.06.2025.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - A dual-polarity ion mobility spectrometer for capturing hyper-fast chromatographic peaks
AU - Nitschke, Alexander
AU - Hitzemann, Moritz
AU - Winkelholz, Jonas
AU - Kirk, Ansgar T.
AU - Schaefer, Christoph
AU - Kobelt, Tim
AU - Thoben, Christian
AU - Lippmann, Martin
AU - Wittwer, Jan A.
AU - Zimmermann, Stefan
N1 - Publisher Copyright: © 2025 The Authors
PY - 2025/6/7
Y1 - 2025/6/7
N2 - For higher analytical performance, ion mobility spectrometers (IMS), especially when analyzing complex mixtures, are often coupled with gas chromatographs (GC). However, analysis time remains a critical parameter in gas chromatography. Therefore, a hyper-fast GC is a promising approach for GC-IMS to combine highest sensitivity of IMS with increased peak capacity while allowing for rapid analysis within the double-digit second range. For simultaneously recording of both ion polarities, a new dual drift tube IMS in axial configuration has been developed that is particularly designed for resolving even hyper-fast GC peaks. Key is a directed sample gas flow through the ionization region giving a small effective detector volume. To avoid condensation of the sample gas, the IMS is isothermally heated to 120 °C. A drift tube length of only LD = 41 mm with a drift voltage of UD = 2.7 kV leads to an IMS repetition rate of 100 Hz and high resolving power of Rp = 60, even for ions with low reduced ion mobility down to 0.43 cm2V-1s-1. This setup can resolve very short GC peaks with full width at half maximum of only 140 ms. For demonstration, two different hop varieties and a mixture of explosives were analyzed within a short time of just 20 s.
AB - For higher analytical performance, ion mobility spectrometers (IMS), especially when analyzing complex mixtures, are often coupled with gas chromatographs (GC). However, analysis time remains a critical parameter in gas chromatography. Therefore, a hyper-fast GC is a promising approach for GC-IMS to combine highest sensitivity of IMS with increased peak capacity while allowing for rapid analysis within the double-digit second range. For simultaneously recording of both ion polarities, a new dual drift tube IMS in axial configuration has been developed that is particularly designed for resolving even hyper-fast GC peaks. Key is a directed sample gas flow through the ionization region giving a small effective detector volume. To avoid condensation of the sample gas, the IMS is isothermally heated to 120 °C. A drift tube length of only LD = 41 mm with a drift voltage of UD = 2.7 kV leads to an IMS repetition rate of 100 Hz and high resolving power of Rp = 60, even for ions with low reduced ion mobility down to 0.43 cm2V-1s-1. This setup can resolve very short GC peaks with full width at half maximum of only 140 ms. For demonstration, two different hop varieties and a mixture of explosives were analyzed within a short time of just 20 s.
KW - Dual-polarity IMS
KW - Explosives
KW - GC-IMS
KW - Hops
KW - Hyper-fast GC
KW - IMS
UR - http://www.scopus.com/inward/record.url?scp=105001490928&partnerID=8YFLogxK
U2 - 10.1016/j.chroma.2025.465923
DO - 10.1016/j.chroma.2025.465923
M3 - Article
AN - SCOPUS:105001490928
VL - 1750
JO - Journal of Chromatography A
JF - Journal of Chromatography A
SN - 0021-9673
M1 - 465923
ER -